UJI EFEKTIVITAS ANTIBAKTERI NANO GEL BAHAN AKTIF EKSTRAK KAYU MANIS (Cinnamomum burmannii) TERHADAP Staphylococcus aureus
DOI:
https://doi.org/10.51544/jf.v7i2.2776Abstract
Nanogel preparations consist of nanoemulsions and gels, where nanoemulsion is one type of preparation that can increase drug permeability on the membrane surface. The use of cinnamon extract as an antibacterial active substance is because cinnamon (Cinnamomum burmannii) contains saponins, tannins, and flavonoids. This study aims to make nanogel preparations with the active ingredient of cinnamon extract and to determine the antibacterial effectiveness of the nanogel as the active ingredient of the cinnamon extract against Staphylococcus aureus. The manufacture of 2% cinnamon extract nanoemulsion aims to make nanoparticle-sized nanogel preparations and as an antibacterial active substance in nanogel preparations against Staphylococcus aureus bacteria. Nanogel preparations were made by adding cinnamon extract nanoemulsion with varying concentrations of F1(2%), F2(4%), F3(6%), and blank formula (F0) as the basis for nanogels without cinnamon extract nanoemulsion. The results showed that the cinnamon extract nanoemulsion could be made into nanogels to produce a thick, brown-colored gel with a characteristic cinnamon smell. The result of the pH of the preparation is 6 according to the pH of the skin, has good homogeneity, and is not irritating to the skin. The PSA test produces a nanoparticle size of 24.2 nm, and the antibacterial effectiveness test of the nanogel preparation can inhibit Staphylococcus aureus bacteria. Produced a moderate inhibition zone category (6.7-7.1 mm) and the F3 formulation (6%) was the best formulation.
Downloads
References
Soc, C. (2020). Chem. Soc. Rev.
Sianturi, A. H. (2018). Universitas Sumatera Utara Skripsi. Analisis Kesadahan Total Dan Alkalinitas Pada Air Bersih Sumur Bor Dengan Metode Titrimetri Di PT Sucofindo Daerah Provinsi Sumatera Utara, 44–48.
Djarot, P., . M., & Ambarwati, D. (2019). LILIN AROMATIK MINYAK ATSIRI KULIT BATANG KAYU MANIS (Cinnamomum burmannii) SEBAGAI REPELEN LALAT RUMAH (Musca domestica). Ekologia, 19(2), 55–64.
https://doi.org/10.33751/ekol.v19i2.1663.
Apriyani, Y. M., Priani, S. E., & Gadri, a. (2015). Aktivitas Antibakteri Minyak Batang Kayu Manis (Cinnamomum burmanii Nees Ex BI.) terhadap Bakteri Propionibacterium acnes. Prosiding Penelitian SPeSIA Unisba 2015, 2460-6, 348–353.
Prabowo, R. (2013). Jurnal Ilmiah Cendekia Eksakta 55. Jurnal Ilmiah Cendekia Eksakta, 82, 55–61.
Firdaus, T. (2014). Efektifitas Ekstrak Bawang Dayak (Eleutherine palmifolia) dalam Menghambat Pertumbuhan Bakteri Staphylococcus aureus. Skripsi, 1, 1–50.
Gunawan, W. (2009). Kualitas Dan Nilai Minyak Atsiri , Implikasi pada Pengembangan Turunannya. Himpunan Kimia Indonesia Jawa Tengah. Kimia Bervisi SETS (Science, Environment, Technology, Society) Kontribusi Bagi Kemajuan Pendidikan Dan Industri, Diselengarakan Himpunan Kimia Indonesia Jawa Tengah, Pada Tangal 21, 1–11.
Hasin, A., & Rachmadana, Z. (2019). Analisis Kadar Kalsium Oksalat (CaC2O4) pada Daun dan Batang Tanaman Bayam di Pasar Tradisional Kota Makassar. Jurnal Media Laboran,9(1), 6–11.
Locke, T., Keat, S., Walker, A., Mackinnon, R., & Read, R. C. (2012). Microbiology and infectious diseases on the move. Microbiology and Infectious Diseases on the Move, 1–242. https://doi.org/10.1201/b13514.
Malangngi, L., Sangi, M., & Paendong, J. (2012). Penentuan Kandungan Tanin dan Uji Aktivitas Antioksidan Ekstrak Biji Buah Alpukat (Persea americana Mill.). Jurnal MIPA, 1(1), 5. https://doi.org/10.35799/jm.1.1.2012.423
Muliadi, D. (2015). Universitas Sumatera Utara 7. 7–37.
This work is licensed under a 
